|
Polycystic Ovary Syndrome
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The association of INSR (INSulin Receptor gene) variants (rs2059807 and rs1799817) with PCOS was established through genome-wide association studies, yet requires validation for the Indian population.
|
31837364 |
2020 |
|
Acanthosis Nigricans
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, a Japanese boy with insulin resistance and acanthosis nigricans was found to be heterozygous for a mutation of the insulin receptor gene that resulted in the replacement of glycine-996 with valine in the ATP binding site of the receptor.
|
31827016 |
2019 |
|
Alzheimer's Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Corrigendum: Involvement of insulin receptor substrates in cognitive impairment and Alzheimer's disease.
|
31823898 |
2020 |
|
Impaired cognition
|
0.180 |
Biomarker
|
disease |
BEFREE |
Corrigendum: Involvement of insulin receptor substrates in cognitive impairment and Alzheimer's disease.
|
31823898 |
2020 |
|
Hyperinsulinism
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The increased insulin sensitivity responsiveness in Grb10-silenced myotubes was associated with higher abundance of the insulin receptor.
|
31794259 |
2020 |
|
Diabetic Neuropathies
|
0.520 |
Biomarker
|
group |
BEFREE |
Here, we created an insulin resistant SC by deleting both insulin receptor (INSR) and insulin-like growth factor receptor 1 (IGF1R), to determine the role of this signaling pathway in development and response to injury in order to understand SC defects in DN.
|
31758725 |
2020 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Gene array analysis of HCC tumour tissue from xenograft mice given IP ascorbate (4.0 g/kg/3 days) identified changes in the transcript levels of 192 genes/ncRNAs involved in insulin receptor signalling, metabolism and mitochondrial respiration.
|
31754384 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Gene array analysis of HCC tumour tissue from xenograft mice given IP ascorbate (4.0 g/kg/3 days) identified changes in the transcript levels of 192 genes/ncRNAs involved in insulin receptor signalling, metabolism and mitochondrial respiration.
|
31754384 |
2019 |
|
Diabetes Mellitus
|
0.200 |
Biomarker
|
group |
BEFREE |
Genetic disorders and insulin receptor disorders, environmental factors, lifestyle choices and toxins are key factors that contribute to DM.
|
31693730 |
2019 |
|
Metabolic Syndrome X
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Rabson-Mendenhall/Donohue syndrome is also caused by defects of the insulin receptor gene (INSR), but is more serious than type A IRS.
|
31677333 |
2019 |
|
Insulin resistance syndrome
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Rabson-Mendenhall/Donohue syndrome is also caused by defects of the insulin receptor gene (INSR), but is more serious than type A IRS.
|
31677333 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
This suggests that treatment of adiponectin effectively improves testicular functions by increasing expression of insulin receptor-mediated increased transport of energy substrate (glucose and lactate) and a marked reduction in oxidative stress are the possible mechanism by which adiponectin effectively improves testicular function in T2D mice.
|
31676315 |
2020 |
|
Colorectal Carcinoma
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
Although these findings need validation, rotating night shift might increase colorectal cancer risk in women with abnormal insulin receptor pathways.
|
31666286 |
2020 |
|
Malignant neoplasm of colon and/or rectum
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
Although these findings need validation, rotating night shift might increase colorectal cancer risk in women with abnormal insulin receptor pathways.
|
31666286 |
2020 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.700 |
Biomarker
|
disease |
BEFREE |
Disruption of INSR-coupled activities has been identified in a wide range of insulin resistance-related diseases such as T2DM.
|
31658625 |
2019 |
|
Metabolic alkalosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Insulin receptor-related receptor (IRR) is a receptor tyrosine kinase of the insulin receptor family and functions as an extracellular alkali sensor that controls metabolic alkalosis in the regulation of the acid-base balance.
|
31615897 |
2019 |
|
Complications of Diabetes Mellitus
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Patients with mutations of the insulin receptor gene (INSR) have extreme insulin resistance and are at risk for early morbidity and mortality from diabetes complications.
|
31588494 |
2020 |
|
Uric acid measurement (procedure)
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels.
|
31578528 |
2019 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Characterizing rare and low-frequency height-associated variants in the Japanese population.
|
31562340 |
2019 |
|
Impaired glucose tolerance
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Congenital beta cell-specific IR knockout (βIRKO) mouse studies have demonstrated the development of age-dependent glucose intolerance.
|
31541682 |
2020 |
|
Impaired insulin secretion
|
0.030 |
Biomarker
|
disease |
BEFREE |
Postnatal knockout of beta cell insulin receptor impaired insulin secretion in male mice exposed to high-fat diet stress.
|
31541682 |
2020 |
|
Vitamin D Deficiency
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Vitamin D deficiency itself also led to decreased LC3 II levels in the liver and decreased insulin receptor staining in the ovaries.
|
31509973 |
2019 |
|
Alzheimer's Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Here, we show that microRNA 7 (miR-7), an abundant microRNA in the brain, targets insulin receptor (INSR), insulin receptor substrate 2 (IRS-2), and insulin-degrading enzyme (IDE), key regulators of insulin homeostatic functions in the central nervous system (CNS) and the pathology of AD.
|
31501273 |
2019 |
|
Neoplasm Metastasis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
Previously published work has demonstrated that overexpression of the insulin receptor isoform A (IR-A) might play a role in cancer progression and metastasis.
|
31480557 |
2019 |
|
Tumor Progression
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
Previously published work has demonstrated that overexpression of the insulin receptor isoform A (IR-A) might play a role in cancer progression and metastasis.
|
31480557 |
2019 |